Analytical Data
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基因名
SYNGAP1
- Application
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别名
SYNGAP1；KIAA1938；Ras/Rap GTPase-activating Protein SynGAP
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96PV0
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表达区间
1161-1343aa
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氨基酸序列
MPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPPPRLQITENGEFRNTADH
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分子量
25.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SYNGAP1 is a gene located on chromosome 6 that encodes a protein involved in synaptic signaling and plasticity, crucial for cognitive functions such as learning and memory. Mutations in SYNGAP1 are associated with a range of neurodevelopmental disorders, including intellectual disability, autism spectrum disorders, and epilepsy. Research has increasingly focused on SYNGAP1 due to its role in various forms of synaptic dysfunction, which are prevalent in these disorders. The study of SYNGAP1 recombinant proteins is essential for understanding the molecular mechanisms underlying these conditions, as well as for the development of targeted therapies. By producing and characterizing SYNGAP1 recombinant proteins, researchers aim to investigate how alterations in SYNGAP1 function contribute to synaptic abnormalities. This investigation may reveal potential biomarkers for diagnosing related neurodevelopmental disorders and provide insights into therapeutic strategies to enhance synaptic function and improve cognitive outcomes. As the field progresses, understanding the pathways and interactions influenced by SYNGAP1 will be pivotal in addressing the challenges posed by SYNGAP1-related conditions, ultimately aiming to translate findings into clinical applications that enhance the quality of life for affected individuals.
