Analytical Data
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基因名
SNAPC2
- Application
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别名
SNAPC2; SNAP45; snRNA-activating protein complex subunit 2; SNAPc subunit 2; Proximal sequence element-binding transcription factor subunit delta; PSE-binding factor subunit delta; PTF subunit delta; Small nuclear RNA-activating complex polypeptide 2; snRNA-activating protein complex 45 kDa subunit; SNAPc 45 kDa subunit
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13487
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表达区间
1-334 aa
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氨基酸序列
MKPPPRRR PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL ARELRGRSEA EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI EVWTDLAEKI TGPLEEALAV AFSQVLTI TEPVTLLHSK PPKPTQARGK PLLLSAPGGQ EDPAPEIPSS APPSSAPR TPDPAPEKPS ESSAGPSTEE DFAVDFEKIY KYLSSVSRSG RSPELSES AVVLDLLMSL PEELPLLPCT ALVEHMTETY LRLTAPQPIP AGGSLGPE GDGAGSKAPE ETPPATEKAE HSELKSPWQA AGICPLNPFL VPLELLGR TPAR
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分子量
35.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNAPC2, a crucial component of the SNAPC (small nuclear RNA-activating protein complex) family, plays an essential role in the transcription of small nuclear RNAs, particularly U6 snRNA, which is vital for pre-mRNA splicing. The protein is composed of multiple domains that facilitate its interaction with other splicing factors and RNA polymerase II, ensuring efficient transcriptional regulation. Research over the years has indicated that SNAPC2 is not only critical for proper snRNA gene expression but also has implications in cell cycle regulation and cell differentiation. Abnormalities in SNAPC2 expression and function have been linked to various diseases, including certain cancers, where altered RNA splicing patterns may contribute to malignancy. Furthermore, the investigation of SNAPC2’s structure and function aids in understanding the molecular mechanisms underlying RNA processing and its diverse regulatory roles in cellular homeostasis. Consequently, studies focusing on the recombinant expression and functional characterization of SNAPC2 are essential for elucidating its biological significance and potential as a therapeutic target in RNA-related pathologies.
