Analytical Data
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Gene name
DTX3
- Application
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Alternative Names
Deltex3; Dtx3; DTX3_HUMAN; Protein deltex 3; Protein deltex-3; RING finger protein 154; RNF154
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N9I9
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Expression Region
1-347aa
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AA Sequence
MSFVLSRMAA CGGTCKNKVT VSKPVWDFLS KETPARLARL REEHRVSILI DGETSDIYVL QLSPQGPPPA PPNGLYLARK ALKGLLKEAE KELKKAQRQG ELMGCLALGG GGEHPEMHRA GPPPLRAAPL LPPGARGLPP PPPPLPPPLP PRLREEAEEQ ESTCPICLGE IQNAKTLEKC RHSFCEGCIT RALQVKKACP MCGRFYGQLV GNQPQNGRML VSKDATLLLP SYEKYGTIVI QYVFPPGVQG AEHPNPGVRY PGTTRVAYLP DCPEGNKVLT LFRKAFDQRL TFTIGTSMTT GRPNVITWND IHHKTSCTGG PQLFGYPDPT YLTRVQEELR AKGITDD
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Molecular Weight
37.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DTX3 (Deltex Homolog 3) is a member of the Deltex family of proteins, which plays a crucial role in Notch signaling, a fundamental pathway involved in cell differentiation, proliferation, and fate determination. Research into DTX3 has gained attention due to its potential implications in various biological processes and diseases, particularly in cancer and developmental disorders. Unlike its well-studied counterparts, DTX1 and DTX2, DTX3's functions remain less understood, prompting investigations into its mechanisms of action and interactions with other cellular factors. Recent studies have indicated that DTX3 may be involved in the regulation of gene expression and has been linked to the modulation of immune responses. Additionally, the characterization of DTX3 as a recombinant protein allows scientists to explore its structural properties and functional dimensions in vitro, enabling insights into its roles at the molecular level. Understanding the biological significance of DTX3 is critical, as it may reveal novel therapeutic targets and strategies for diseases where Notch signaling is disrupted. Thus, ongoing research focused on the recombinant expression and functional characterization of DTX3 is essential for elucidating its contributions to cell biology and disease pathology.
