Analytical Data
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基因名
UCHL5IP
- Application
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别名
26S proteasome-associated UCH interacting Protein 1; 26S proteasome-associated UCH37-interacting Protein 1; Expressed-Xq28STS Protein; HAUS augmin-like complex subunit 7; Haus7; HAUS7_HUMAN; HSXQ28ORF; UCH37 interacting Protein 1; UCHL5 interacting Protein; UCHL5-interacting Protein; UCHL5IP; UIP1; X-linked Protein STS1769
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99871
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表达区间
1-368 aa
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氨基酸序列
MGGARLGARN MAGQDAGCGR GGDDYSEDEG DSSVSRAAVE VFGKLKDLNC PFLEGLYITE PKTIQELLCS PSEYRLEILE WMCTRVWPSL QDRFSSLKGV PTEVKIQEMT KLGHELMLCA PDDQELLKGC ACAQKQLHFM DQLLDTIRSL TIGCSSCSSL MEHFEDTREK NEALLGELFS SPHLQMLLNP ECDPWPLDMQ PLLNKQSDDW QWASASAKSE EEEKLAELAR QLQESAAKLH ALRTEYFAQH EQGAAAGAAD ISTLDQKLRL VTSDFHQLIL AFLQVYDDEL GECCQRPGPD LHPCGPIIQA THQNLTSYSQ LLQVVMAVAD TSAKAVETVK KQQGEQICWG GSSSVMSLAT KMNELMEK
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分子量
39.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UCHL5 (Ubiquitin C-terminal hydrolase L5) is a member of the ubiquitin protease family, playing a crucial role in the regulation of ubiquitin-mediated protein degradation. It is primarily involved in the removal of ubiquitin from modified proteins, thus influencing various cellular processes such as cell cycle progression, DNA repair, and apoptosis. The study of UCHL5 is increasingly significant due to its potential implications in various diseases, including cancer and neurodegenerative disorders. Notably, aberrant expression levels of UCHL5 have been linked to tumor progression and poor prognosis in certain cancers, highlighting its role as a potential biomarker and therapeutic target. The generation of recombinant UCHL5 proteins allows for detailed biochemical characterization and investigation of its enzymatic activity, substrate specificity, and physiological functions. Researchers are particularly focused on elucidating the structural features of UCHL5 that confer its functional properties, as well as its interactions with other molecular partners in the ubiquitin-proteasome system. Understanding these mechanisms may provide insights into the development of novel therapeutic strategies aimed at modulating UCHL5 activity in disease contexts. Furthermore, the exploration of UCHL5 inhibitors or activators may offer new avenues for cancer treatment, as well as strategies for neuroprotection in neurodegenerative diseases. Overall, the study of recombinant UCHL5 proteins is critical for advancing our knowledge of ubiquitin signaling pathways and their implications in human health and disease.
