Analytical Data
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基因名
UFL1
- Application
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别名
E3 UFM1-Protein ligase 1; KIAA0776; LZAP-binding Protein; Maxer; NLBP; RCAD; UFL1; UFL1_HUMAN; UFM1 specific ligase 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94874
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表达区间
2-794 aa
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氨基酸序列
ADAWEEIRR LAADFQRAQF AEATQRLSER NCIEIVNKLI AQKQLEVVHT LDGKEYITPA QISKEMRDEL HVRGGRVNIV DLQQVINVDL IHIENRIGDI IKSEKHVQLV LGQLIDENYL DRLAEEVNDK LQESGQVTIS ELCKTYDLPG NFLTQALTQR LGRIISGHID LDNRGVIFTE AFVARHKARI RGLFSAITRP TAVNSLISKY GFQEQLLYSV LEELVNSGRL RGTVVGGRQD KAVFVPDIYS RTQSTWVDSF FRQNGYLEFD ALSRLGIPDA VSYIKKRYKT TQLLFLKAAC VGQGLVDQVE ASVEEAISSG TWVDIAPLLP TSLSVEDAAI LLQQVMRAFS KQASTVVFSD TVVVSEKFIN DCTELFRELM HQKAEKEMKN NPVHLITEED LKQISTLESV STSKKDKKDE RRRKATEGSG SMRGGGGGNA REYKIKKVKK KGRKDDDSDD ESQSSHTGKK KPEISFMFQD EIEDFLRKHI QDAPEEFISE LAEYLIKPLN KTYLEVVRSV FMSSTTSASG TGRKRTIKDL QEEVSNLYNN IRLFEKGMKF FADDTQAALT KHLLKSVCTD ITNLIFNFLA SDLMMAVDDP AAITSEIRKK ILSKLSEETK VALTKLHNSL NEKSIEDFIS CLDSAAEACD IMVKRGDKKR ERQILFQHRQ ALAEQLKVTE DPALILHLTS VLLFQFSTHS MLHAPGRCVP QIIAFLNSKI PEDQHALLVK YQGLVVKQLV SQSKKTGQGD YPLNNELDKE QEDVASTTRK ELQELSSSIK DLVLKSRKSS VTEE
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分子量
89.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UFL1 (Ubiquitin Fusion Protein 1) is a critical regulator of protein homeostasis and quality control within the cell. Research into UFL1 has gained momentum due to its dual role in ubiquitin-mediated degradation and the formation of protein aggregates, particularly under stress conditions. UFL1 is involved in the ubiquitin-proteasome system, where it influences the tagging of misfolded or damaged proteins for degradation, thereby maintaining cellular integrity. Additionally, UFL1 is implicated in various cellular processes, including cell cycle regulation, apoptosis, and response to oxidative stress. Dysregulation of UFL1 has been associated with several diseases, including cancer and neurodegenerative disorders, making it a potential therapeutic target. Recent studies have focused on elucidating the molecular mechanisms through which UFL1 operates, its interactions with other cellular components, and the implications of these interactions in disease progression. Understanding UFL1's functional dynamics is crucial for developing strategies to manipulate its activity, which could lead to innovative treatments for conditions arising from proteostasis imbalance. As such, UFL1 emerges as a significant focus in the field of cellular biology and therapeutic research, with ongoing studies aimed at uncovering the full breadth of its biological roles and potential as a drug target.
