Analytical Data
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基因名
UNKL
- Application
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别名
C16orf28; FLJ12623; FLJ23360; KIAA0734; MGC5179; Putative E3 ubiquitin-Protein ligase UNKL; RING finger Protein unkempt-like; Unkempt homolog (Drosophila) like; Unkempt like; Unkempt like Protein; Unkl; UNKL_HUMAN; ZC3H5L; ZC3HDC5L; Zinc finger CCCH domain-containing Protein 5-like
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H9P5
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表达区间
1-680 aa
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氨基酸序列
MPSVSKAAAA ALSGSPPQTE KPTHYRYLKE FRTEQCPLFS QHKCAQHRPF TCFHWHFLNQ RRRRPLRRRD GTFNYSPDVY CSKYNEATGV CPDGDECPYL HRTTGDTERK YHLRYYKTGT CIHETDARGH CVKNGLHCAF AHGPLDLRPP VCDVRELQAQ EALQNGQLGG GEGVPDLQPG VLASQAMIEK ILSEDPRWQD ANFVLGSYKT EQCPKPPRLC RQGYACPHYH NSRDRRRNPR RFQYRSTPCP SVKHGDEWGE PSRCDGGDGC QYCHSRTEQQ FHPESTKCND MRQTGYCPRG PFCAFAHVEK SLGMVNEWGC HDLHLTSPSS TGSGQPGNAK RRDSPAEGGP RGSEQDSKQN HLAVFAAVHP PAPSVSSSVA SSLASSAGSG SSSPTALPAP PARALPLGPA SSTVEAVLGS ALDLHLSNVN IASLEKDLEE QDGHDLGAAG PRSLAGSAPV AIPGSLPRAP SLHSPSSAST SPLGSLSQPL PGPVGSSAMT PPQQPPPLRS EPGTLGSAAS SYSPLGLNGV PGSIWDFVSG SFSPSPSPIL SAGPPSSSSA SPNGAELARV RRQLDEAKRK IRQWEESWQQ VKQVCDAWQR EAQEAKERAR VADSDRQLAL QKKEEVEAQV IFQLRAKQCV ACRERAHGAV LRPCQHHILC EPCAATAPEC PYCKGQPLQW
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分子量
73.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UNKL is a protein that belongs to the family of E3 ubiquitin ligases, which play a crucial role in the ubiquitin-proteasome system, a key mechanism for regulating protein degradation and maintaining cellular homeostasis. Recent research has highlighted the significance of UNKL in various biological processes, including cell cycle regulation, DNA damage response, and immune regulation. Its involvement in these pathways suggests that UNKL may be associated with several diseases, including cancer and neurodegenerative disorders. Understanding the structure and function of UNKL is vital for elucidating its role in cellular mechanisms, as alterations in its activity can lead to pathological conditions. Recent advances in recombinant protein technology have enabled scientists to produce UNKL in sufficient quantities for detailed biochemical and structural studies, facilitating the exploration of its interaction with substrates and other cellular partners. The study of UNKL not only provides insights into the fundamental aspects of ubiquitination but also opens up potential therapeutic avenues for targeting related diseases, making it a focal point of ongoing research in molecular biology and medicine.
