Analytical Data
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Gene name
GRM3
- Application
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Alternative Names
GLUR3; GPRC1C; MGLUR3; MGlu3; Glutamate Receptor, Metabotropic 3
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14832
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Expression Region
Asp568~Phe819
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Molecular Weight
58kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRM3, or metabotropic glutamate receptor 3, plays a crucial role in the central nervous system as a key modulator of synaptic transmission and plasticity. Dysfunctional signaling of GRM3 has been implicated in a variety of neuropsychiatric disorders, including schizophrenia, depression, and autism spectrum disorders, making it a significant target for pharmacological research. The receptor's role in glutamate signaling highlights its importance in regulating excitatory neurotransmission, which is essential for cognitive processes such as learning and memory. Studies have shown that GRM3 can influence neuronal development and survival, further emphasizing its potential as a therapeutic target. The development of recombinant GRM3 proteins allows researchers to investigate the receptor's structure-function relationship, as well as its interactions with ligands and intracellular signaling pathways. These studies contribute to an understanding of how GRM3 dysregulation may lead to neurodevelopmental and psychiatric disorders, paving the way for novel treatment strategies that could modulate its activity. As research continues to unravel the complexities of GRM3 function, the potential for targeted therapies that address its role in disease mechanisms remains a promising frontier in neuropharmacology.
