Analytical Data
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Gene name
SYNCRIP
- Application
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Alternative Names
Glycine- and tyrosine-rich RNA-binding protein ;GRY-RBPNS1-associated protein 1Synaptotagmin-binding, Cytoplasmic domain RNA-interacting protein
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60506
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Expression Region
2-191aa
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Molecular Weight
47.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SYNCRIP, a member of the synaptotagmin family, is an RNA-binding protein that plays a crucial role in regulating RNA metabolism, transport, and stability in various cellular contexts. Initially discovered for its involvement in synaptic functions, subsequent studies have revealed its diverse biological functions, including its role in neuronal development and synaptic plasticity. In addition to its neural implications, SYNCRIP has been shown to interact with a variety of RNA targets, influencing gene expression and cellular responses to stress. Given its pivotal roles, researchers are increasingly focused on understanding the molecular mechanisms by which SYNCRIP exerts its effects, particularly in the context of neurodegenerative diseases and other disorders where RNA metabolism is disrupted. Exploring these pathways could provide insights into potential therapeutic targets, emphasizing the importance of SYNCRIP in maintaining cellular homeostasis and its contributions to various pathophysiological conditions. Understanding SYNCRIP's interactions and functions could pave the way for novel therapeutic strategies in treating diseases associated with RNA dysregulation, highlighting its significance in both basic biology and clinical research.
