Analytical Data
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Gene name
FGFR-2
- Application
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Biological Activity
Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb/c 3T3 mouse fibroblasts. The ED50 for this effect is 1.667 ng/mL, corresponding to a specific activity is 6.0×105 units/mg. Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb/c 3T3 mouse fibroblasts. The ED50 for this effect is 1.667 ng/mL, corresponding to a specific activity is 6.0×105 units/mg.
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Alternative Names
Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
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Species
Mouse
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
E9Q5C3
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Expression Region
R22-E263
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AA Sequence
RPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLTVLPKQQAPVREKEITASPDYLE
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Protein Length
Partial
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Molecular Weight
40-7 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast Growth Factor Receptor 2 (FGFR-2) is a vital member of the FGFR family, known for its critical roles in cell proliferation, differentiation, and survival. It is particularly implicated in various physiological processes, including angiogenesis and wound healing. Dysregulation or mutations in FGFR-2 are associated with several diseases, including certain cancers and congenital disorders such as Apert syndrome. The study of FGFR-2 has gained prominence due to its potential as a therapeutic target. Researchers have been focusing on developing recombinant FGFR-2 proteins to understand its structure-function relationships and the mechanisms underlying its activation. Such recombinant proteins can be used in a variety of applications, such as drug screening, the development of targeted therapies, and investigating FGFR-2's role in cell signaling pathways. Furthermore, the generation of FGFR-2 variants and their interactions with specific ligands can provide insights into the receptor's ligand-binding dynamics and subsequent downstream signaling effects. As FGFR-2 continues to be a focal point in cancer biology and regenerative medicine, the development and characterization of its recombinant proteins could lead to novel therapeutic strategies that exploit this receptor's essential functions.
