Analytical Data
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Gene name
TAP1
- Application
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Alternative Names
APT1; ABC17; ABCB2; PSF1; RING4; Y3; TAP1N; Peptide Supply Factor 1; Atp-Binding Cassette,Subfamily B,Member 2; Peptide transporter involved in antigen processing 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q03518
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Expression Region
Tyr525~Glu808
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Molecular Weight
40kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TAP1, or Transporter Associated with Antigen Processing 1, is a crucial protein involved in the immune response, specifically in the presentation of antigens to cytotoxic T cells. This transmembrane protein plays a vital role in the transport of peptides generated from intracellular protein degradation into the endoplasmic reticulum, where they bind to Major Histocompatibility Complex (MHC) class I molecules. The TAP1 protein functions as part of a heterodimer with TAP2, forming a peptide transport complex essential for the immune surveillance mechanism. Research on recombinant TAP1 has gained traction due to its potential implications in immunotherapy and vaccine development. By producing TAP1 as a recombinant protein, researchers aim to better understand its structure-function relationships, assess its role in antigen processing, and explore its potential as a target for enhancing immune responses against tumors and infectious diseases. Additionally, recombinant TAP1 can serve as a valuable tool for studying the molecular mechanisms of antigen presentation and for investigating the interplay between viral infections and immune evasion strategies. Understanding the characteristics and functions of TAP1 not only contributes to the fundamental knowledge of immunology but also paves the way for innovative therapeutic approaches in enhancing immune responses.
