Analytical Data
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基因名
XPB
- Application
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别名
ERCC3; XPBC; BTF2; RAD25; TFIIH; GTF2H; Excision Repair Cross-Complementing Rodent Repair Deficiency,Complementation Group 3; Basic transcription factor 2 89 kDa subunit
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P19447
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表达区间
Arg542~Ala702
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分子量
22kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XPB, also known as ERCC3, is a crucial protein involved in the DNA repair mechanism, specifically in the nucleotide excision repair (NER) pathway. This protein plays a vital role in recognizing and repairing bulky DNA adducts that can arise from environmental agents, such as UV radiation and chemical mutagens. Mutations in the XPB gene can lead to xeroderma pigmentosum, a rare genetic disorder characterized by extreme sensitivity to sunlight and a high predisposition to skin cancers. Research on XPB recombinant proteins has gained importance due to their potential therapeutic applications in gene therapy and cancer treatment, as well as their fundamental role in understanding the mechanisms of DNA repair and the cellular response to genotoxic stress. By studying the structure and function of XPB, scientists aim to develop strategies to enhance DNA repair processes or to target cancer cells more effectively, leveraging the protein’s function within the NER pathway. These studies have broader implications for unraveling the complexities of genomic stability, aging, and the cellular response to DNA damage, making XPB a focal point in molecular biology and therapeutic research.
