Analytical Data
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Gene name
Smpdl3b
- Application
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Alternative Names
/
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Species
Mouse
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P58242
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Expression Region
19-456aa
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Molecular Weight
57.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Smpdl3b, or sphingomyelin phosphodiesterase-like 3B, is an important enzyme involved in the metabolism of sphingolipids, which play critical roles in cell signaling and membrane composition. Recent research has highlighted its potential implications in various physiological and pathological processes, including neurodegenerative diseases, cancer, and immune responses. The functional characterization of Smpdl3b as a recombinant protein has become a focus of scientific inquiry to elucidate its biological roles. Researchers aim to purify and study this protein to better understand its enzymatic activity and interactions with other cellular molecules. By generating Smpdl3b in a recombinant form, scientists can investigate its effect on lipid signaling pathways and its contribution to cell proliferation, apoptosis, and inflammation. Furthermore, this research may open avenues for therapeutic advancements, as targeting Smpdl3b could offer new strategies for manipulating sphingolipid metabolism in various diseases. Overall, the study of Smpdl3b and its recombinant expression is pivotal for uncovering the intricate mechanisms of sphingolipid biology and its clinical relevance.
