Analytical Data
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Gene name
TUBa1B
- Application
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Alternative Names
Alpha-tubulin ubiquitous; Tubulin K-alpha-1; Tubulin alpha-ubiquitous chain
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P68363
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Expression Region
Met1~Tyr451
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Molecular Weight
54kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TUBA1B is a gene encoding a member of the alpha-tubulin protein family, which is crucial for the formation of microtubules, essential components of the cytoskeleton in eukaryotic cells. Microtubules play key roles in various cellular processes, including cell division, intracellular transport, and maintenance of cell shape. Mutations in the TUBA1B gene have been associated with a range of neurological disorders, most notably malformations of cortical development and other neurodevelopmental conditions. These mutations can lead to defects in neuronal migration and differentiation, highlighting the importance of TUBA1B in brain development. The research on TUBA1B recombinant proteins focuses on understanding its structural and functional properties, which is critical for elucidating the mechanisms through which mutations affect cellular function and contribute to disease. By producing and analyzing TUBA1B recombinant proteins, researchers aim to develop models that can assess the impact of specific mutations, ultimately contributing to the development of targeted therapies for associated disorders. Furthermore, studying TUBA1B provides valuable insights into the broader role of tubulin dynamics in cellular processes, paving the way for advances in cell biology and therapeutic interventions for related diseases.
