Analytical Data
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基因名
CACNa1D
- Application
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别名
CACH3; CACN4; CACNL1A2; CCHL1A2; Cav1.3; Voltage-gated calcium channel subunit alpha Cav1.3; Calcium channel, L type, alpha-1 polypeptide, isoform 2
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q01668
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表达区间
Met1~Gly95
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分子量
48kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CACNa1D is a member of the voltage-gated calcium channel (VGCC) family, specifically the CaV1.3 subtype, which plays a critical role in various physiological processes such as muscle contraction, neurotransmitter release, and hormone secretion. Research on CACNa1D has gained momentum due to its involvement in multiple pathological conditions, including cardiac arrhythmias, sensorineural hearing loss, and certain neurodegenerative diseases. This protein is essential for maintaining calcium homeostasis within cells, and its dysregulation can lead to serious health issues. Given its significance, the recombinant expression of CACNa1D in heterologous systems, such as mammalian cells or yeast, has become a focal point for researchers aiming to uncover its functional properties, structure-function relationships, and potential pharmacological interactions. Scientists are keen on utilizing these recombinant proteins for functional assays, biophysical characterization, and drug screening, which can facilitate the development of targeted therapies for disorders linked to calcium channel dysfunction. As the study of CACNa1D advances, it holds the promise of offering deeper insights into the mechanisms of calcium signaling and the development of novel treatments for associated diseases.
