Analytical Data
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Gene name
SNPH
- Application
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Alternative Names
bA314N13.5; KIAA0374; Snph; SNPH_HUMAN; Syntaphilin
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15079
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Expression Region
1-424aa
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Molecular Weight
62 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNPH (Synphilin-1) is a protein that has garnered attention in neurobiology due to its association with the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Originally identified as a binding partner of alpha-synuclein, a key protein implicated in the formation of Lewy bodies, SNPH plays a significant role in cellular processes such as synaptic function and protein aggregation. Research into SNPH's structural properties and functional implications suggests that it may influence the stability of alpha-synuclein aggregates or alter cellular responses to stress. Given the increasing prevalence of neurodegenerative diseases and the critical need for therapeutic targets, understanding the role of SNPH in neurodegeneration could offer insights into disease mechanisms and potential interventions. Recent studies have highlighted the importance of studying SNPH in various model systems, including transgenic mice and cell cultures, to elucidate its function in cellular pathways related to neurodegeneration. By exploring SNPH's interactions and effects at the molecular level, researchers aim to identify new biomarkers and therapeutic strategies for mitigating the progression of neurodegenerative diseases. The ongoing investigation into SNPH's mechanisms holds promise for understanding complex neurobiological processes and developing innovative treatments for disorders characterized by protein misfolding and aggregation.
