Analytical Data
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基因名
LPAR1
- Application
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别名
LPAR1；EDG2；LPA1；Lysophosphatidic acid receptor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92633
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表达区间
1-364aa
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氨基酸序列
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSK LVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGL AYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITV FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAP LYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNR DTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNH TILAGVHSNDHSVV
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分子量
68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LPAR1, or Lysophosphatidic Acid Receptor 1, is a G-protein-coupled receptor that plays a crucial role in various physiological and pathological processes, including cell proliferation, survival, migration, and differentiation. It is activated by lysophosphatidic acid (LPA), a bioactive lipid involved in several cellular signaling pathways. Significant research has linked LPAR1 to conditions such as cancer, fibrosis, and neurodegenerative diseases, highlighting its potential as a therapeutic target. Due to its involvement in disease progression, the characterization and production of LPAR1 recombinant proteins are of great interest. By utilizing techniques such as molecular cloning and expression in suitable host systems, researchers aim to produce functional LPAR1 proteins for structural and functional studies. These studies are vital for understanding the receptor's signaling mechanisms, interaction with ligands, and potential modulation by small molecules. Furthermore, LPAR1's role in promoting tumor growth and metastasis has made it a focus in cancer research, leading to the exploration of LPAR1 antagonists as novel cancer therapies. Overall, the investigation of LPAR1, particularly through the development of recombinant proteins, serves as a foundation for both basic research and the advancement of therapeutic strategies targeting various diseases.
