Analytical Data
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基因名
CRMP1
- Application
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别名
CRMP1；DPYSL1；ULIP3;Dihydropyrimidinase-related Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14194
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表达区间
1-572aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSEFMSYQGKKSIPHITSDRLLIKGGRII NDDQSLYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIPGGIDVNTY LQKPSQGMTAADDFFQGTRAALVGGTTMIIDHVVPEPGSSLLTSFEKWHE AADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDVYQ MSDSQLYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHAL SRPEELEAEAVFRAITIAGRINCPVYITKVMSKSAADIIALARKKGPLVF GEPIAASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYLTSLLACGD LQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWDKAVATGKM DENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKLKTITAKSH KSAVEYNIFEGMECHGSPLVVISQGKIVFEDGNINVNKGMGRFIPRKAFP EHLYQRVKIRNKVFGLQGVSRGMYDGPVYEVPATPKYATPAPSAKSSPSK HQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG
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分子量
65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRMP1 (Collapsin Response Mediator Protein 1) is a pivotal protein involved in neuronal development and axon guidance. A member of the CRMP family, CRMP1 has garnered significant interest due to its role in neurotrophic signaling and its implications in neurodegenerative disorders. Research indicates that CRMP1 interacts with various signaling pathways, influencing cytoskeletal dynamics and neuronal differentiation. Its involvement in the growth cone dynamics of developing neurons highlights its potential as a target for therapeutic strategies aimed at facilitating nerve regeneration. Furthermore, studies have implicated CRMP1 in the pathology of conditions such as Alzheimer’s disease, where its dysregulation may contribute to neuroinflammation and synaptic dysfunction. The need to understand CRMP1's structure and function has fueled the production of recombinant CRMP1 protein, which serves as a valuable tool for elucidating its biological activities and interactions within cellular contexts. By employing recombinant technology, researchers aim to dissect the molecular mechanisms underlying CRMP1’s roles in neuronal signaling and its potential in therapeutic interventions for neurodegenerative diseases. The recombinant CRMP1 protein can further assist in screening for compounds that might modulate its function, thereby advancing drug discovery efforts in neuroprotection and neuroregeneration. Overall, the study of CRMP1, through the lens of recombinant protein research, holds promise for unveiling new avenues in neuroscience and for developing innovative therapeutic approaches to tackle complex neural disorders.
