Analytical Data
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基因名
CRLF2
- Application
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别名
CRLF2；CRL2；ILXR；TSLPR;Cytokine receptor-like factor 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HC73
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表达区间
23-231aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSQGGAAEGVQIQIIYFNLETVQVTWNAS KYSRTNLTFHYRFNGDEAYDQCTNYLLQEGHTSGCLLDAEQRDDILYFSI RNGTHPVFTASRWMVYYLKPSSPKHVRFSWHQDAVTVTCSDLSYGDLLYE VQYRSPFDTEWQSKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTY PSDWSEVTCWQRGEIRDACAETPTPPKPKLSK
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分子量
27 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRLF2 (Cytokine Receptor-Like Factor 2) is a protein that plays a crucial role in various physiological processes, including hematopoiesis and immune responses. Its significance has been highlighted in the context of hematological malignancies, particularly in acute lymphoblastic leukemia (ALL), where CRLF2 is often found to be overexpressed or mutated. This dysregulation is associated with poor prognosis in patients, prompting extensive research into its functional implications and pathways. The interest in CRLF2 also stems from its involvement in cytokine signaling, which is critical for cell proliferation and differentiation. Recent studies have focused on the recombinant expression of CRLF2 to investigate its structure-function relationship, explore its interactions with other signaling molecules, and assess its potential as a therapeutic target. Additionally, the generation of CRLF2 recombinant proteins enables the development of specific antibodies for diagnostic tools and research applications. Understanding the mechanisms by which CRLF2 contributes to leukemogenesis may provide insights into novel treatment strategies, making it a pivotal area of research in cancer biology and therapeutics.
