Analytical Data
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基因名
LRRN1
- Application
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别名
LRRN1；KIAA1497；Leucine-rich repeat neuronal Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6UXK5
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表达区间
26-631aa
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氨基酸序列
SIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTLLDGTQVLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKNAAFAVDISDQETSTA
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分子量
84.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRRN1, or Leucine-Rich Repeat Neuronal 1, is a protein implicated in various neurological processes and is particularly prominent in the development and functioning of the nervous system. Research has shown that LRRN1 plays a crucial role in presynaptic function and synaptic signaling, impacting neuronal connectivity and plasticity. Dysfunctional LRRN1 expression has been associated with several neurodevelopmental disorders, including schizophrenia and autism spectrum disorders, making it a significant target for understanding the underlying molecular mechanisms of these conditions. Furthermore, the protein's interaction with other key synaptic proteins suggests that it may be involved in the formation and maintenance of synaptic structures. The production of LRRN1 recombinant proteins has become an essential tool for further elucidating its biological functions and interactions. This facilitates the exploration of the potential therapeutic avenues for neurological disorders, as well as the protein's utility in drug screening and developmental studies. Consequently, detailed investigations into LRRN1's structure, function, and signaling pathways hold promise for advancing our understanding of neuronal health and the etiology of neuropsychiatric conditions.
