Analytical Data
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基因名
HSPB6
- Application
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别名
HSPB6;Heat shock Protein beta-6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14558
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表达区间
1-160aa
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氨基酸序列
MEIPVPVQPS WLRRASAPLP GLSAPGRLFD QRFGEGLLEA ELAALCPTTL APYYLRAPSV ALPVAQVPTD PGHFSVLLDV KHFSPEEIAV KVVGEHVEVH ARHEERPDEH GFVAREFHRR YRLPPGVDPA AVTSALSPEG VLSIQAAPAS AQAPPPAAAK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HSPB6, a member of the small heat shock protein (sHSP) family, has garnered significant interest in recent years due to its critical role in cellular stress responses and protein quality control. This protein is primarily expressed in embryonic and postnatal tissues, particularly in the heart and skeletal muscles, where it helps protect cells from stress-induced damage. Studies have indicated that HSPB6 functions as a molecular chaperone, preventing the aggregation of misfolded proteins and facilitating their proper refolding. Dysregulation or mutations in HSPB6 have been linked to various cardiac and neuromuscular diseases, highlighting its potential as a therapeutic target. The recombinant production of HSPB6 allows researchers to investigate its molecular properties, interactions with other proteins, and its functional role under pathological conditions. Understanding the mechanisms by which HSPB6 exerts its protective effects could open new avenues for the development of novel treatments for muscle degenerative diseases and cardiomyopathies. As such, research on HSPB6 recombinant proteins is poised to contribute valuable insights into cell survival mechanisms and the broader field of proteostasis.
