Analytical Data
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Gene name
KIAA1586
- Application
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Alternative Names
KIAA1586; E3 SUMO-protein ligase KIAA1586; EC 2.3.2.-; E3 SUMO-protein transferase KIAA1586
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HCI6
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Expression Region
1-787aa
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AA Sequence
MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPSRPVLEYIDLVCGDDENPSAYYSDILFPKMPKRQGDFLHFLNVKKVKTDTENNEVSKNHCRLSKAKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLGCKDCSAVRHLGSKAEKHVHVSKEWIAYLVTPNGSNKTTRQASLRKKIREHDVSKAHGKIQDLLKESTNDSICNLVHKQNNKNIDATVKVFNTVYSLVKHNRPLSDIEGARELQEKNGEVNCLNTRYSATRIAEHIAKEMKMKIFKNIIEENAKICIIIDEASTVSKKTTLVIYLQCTIQSAPAPVMLFVALKELVSTIAECIVNTLLTTLNDCGFTNEYLKANLIAFCSDGANTILGRKSGVATKLLENFPEIIIWNCLNHRLQLSLDDSISEIKQINHLKIFIDKIYSIYHQPNKNQTKLLGTVAKELETEIIKIGRVMGPRWAACSLQAATAVWHAYPILYMHFSHSYSGLAKRLANINFLQDLALMIDILEEFSVLSTALQSRSTNIKKAQKLIKRTIRALENLKIGTGKYESQIEDLIKSDKFKDIPFNKNNKFNALPRSILLDNIIQHMNLRLLSDRNHEDIFNYFDLLEPSTWPYEEITSPWIAGEKTLFHLCKILKYEVDLNDFREFVNNNIKSNNVSIPTTIYKAKKIVSTIAINSAEAERGFNLMNIICTRVRNSLTIDHVSDLMTINLLGKELADWDATPFVKSWSNCNHRLATDTRVRQKSTKVFHENQLAIWNLK
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Molecular Weight
116.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KIAA1586, a gene located on chromosome 12, has garnered attention in recent years due to its involvement in various cellular processes and potential implications in human health. Initially characterized through large-scale sequencing projects, KIAA1586 encodes a protein that is hypothesized to play a role in cellular signaling and regulation pathways. Research has indicated that KIAA1586 might be linked to neurological functions and development, as its expression patterns have been observed in brain tissues. Additionally, some studies suggest that abnormalities in KIAA1586 expression could correlate with certain diseases, including neurodegenerative disorders and cancers. As a result, scientists have focused on the structural and functional properties of the KIAA1586 recombinant protein to uncover its precise biological roles. Utilizing techniques such as gene cloning and protein purification, researchers aim to elucidate the interactions of KIAA1586 at the molecular level, which could lead to advancements in therapeutic strategies for conditions associated with KIAA1586 dysregulation. Furthermore, understanding the mechanisms whereby KIAA1586 exerts its effects may provide insights into broader questions of cell biology and pathology, underscoring its potential significance within the field of biomolecular research. The ongoing exploration of KIAA1586 is a promising avenue for uncovering novel targets for intervention in associated health issues, making it a compelling subject of study in the realms of genetics, molecular biology, and biomedicine.
