Analytical Data
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Gene name
RORa
- Application
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Alternative Names
RORa；NR1F1；RZRA；Nuclear receptor ROR-alpha
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35398
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Expression Region
1-468aa
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AA Sequence
MMYFVIAAMKSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
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Molecular Weight
57.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RORa (Retinoic Acid Receptor-Related Orphan Receptor alpha) is a member of the nuclear receptor superfamily that plays a crucial role in regulating various physiological processes, including metabolic homeostasis, immune response, and circadian rhythm. Its significance has become increasingly evident in recent years, as it is implicated in several diseases, including autoimmune disorders, metabolic syndrome, and cancer. Research into RORa's function has revealed its potential as a therapeutic target, driving the need for the development of recombinant RORa proteins for experimental studies. These recombinant proteins facilitate the exploration of RORa's molecular mechanisms, including its role in gene transcription and interaction with other signaling pathways. Additionally, studying RORa's structure and function through recombinant technology provides insights into its ligand-binding properties and the effects of various small molecules, which can lead to the discovery of novel drugs. Understanding RORa's biological roles through these proteins can pave the way for innovative treatments for RORa-related diseases, highlighting its importance in both basic and applied research.
