Analytical Data
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基因名
Zic
- Application
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别名
Zic；ZIC；ZNF201；Zinc finger Protein ZIC 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15915
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表达区间
1-447aa
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氨基酸序列
MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN PSSHELASAG QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF LFRNRGFGDA AAAASAQHSL FAASAGGFGG PHGHTDAAGH LLFPGLHEQA AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ VTSPRSEHYA APQLHGYGPM NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK SCNKTFSTMH ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK KHMHVHTSDK PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG YESSTPPTIV SPSTDNPTTS SLSPSSSAVH HTAGHSALSS NFNEWYV
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分子量
48.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Zic proteins are a family of zinc finger transcription factors that play critical roles in various biological processes, including neural development, limb development, and the regulation of gene expression. These proteins are characterized by their distinct zinc finger domains, which enable them to bind DNA and interact with other proteins. Research has shown that Zic proteins are involved in the regulation of key signaling pathways, such as the Sonic Hedgehog (Shh) pathway, which is essential for proper embryonic development and patterning. Dysregulation of Zic proteins has been implicated in various developmental disorders and diseases, including congenital malformations and cancers. As a result, understanding the structure and function of Zic proteins, particularly through the study of their recombinant forms, has become a significant area of interest in developmental biology and molecular genetics. Recombinant Zic proteins allow researchers to investigate their functional properties, interaction with target genes, and the mechanisms underlying their regulatory roles. This research not only enhances our fundamental understanding of developmental processes but also opens potential avenues for therapeutic interventions in conditions associated with Zic protein dysregulation.
