Analytical Data
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基因名
RGS21
- Application
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别名
RGS21;Regulator of G-Protein signaling 21
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q2M5E4
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表达区间
1-152aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSH MPVKCC FYRSPTAETM TWSENMDTLL ANQAGLDAFR IFLKSEFSEE NVEFWLACED FKKTKNADKI ASKAKMIYSE FIEADAPKEI NIDFGTRDLI SKNIAEPTLK CFDEAQKLIY CLMAKDSFPR FLKSEIYKKL VNSQQVPNHK KWLPFL
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分子量
20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS21 (Regulator of G-protein signaling 21) is a member of the RGS protein family, which plays a crucial role in modulating G-protein-coupled receptor (GPCR) signaling pathways. GPCRs are vital for various physiological processes and are significant targets for drug development due to their involvement in numerous diseases. RGS proteins, including RGS21, act as facilitators that accelerate the GTPase activity of G-proteins, thereby influencing signal transduction and maintaining cellular homeostasis. Research on RGS21 has gained momentum due to its unique structural features and its potential role in regulating specific GPCRs associated with neurological functions and cardiovascular health. Elevated expression levels of RGS21 have been implicated in certain pathological conditions, such as heart failure and neurodegenerative diseases, making it a potential therapeutic target. Understanding the structure-function relationship of RGS21 through recombinant protein studies can shed light on its mechanisms of action and interaction with GPCRs, ultimately guiding the development of innovative pharmacological strategies. This research not only enhances our comprehension of GPCR signaling but also opens avenues for targeted therapies that can modulate these pathways with higher specificity and fewer side effects.
