Analytical Data
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基因名
RUVBL1
- Application
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别名
TRRAP;PAF400;Transformation/transcription domain-associated Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y265
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表达区间
1-456aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMKIEEVKSTTKTQRIASHSHVKGLGLDESG LAKQAASGLVGQENAREACGVIVELIKSKKMAGRAVLLAGPPGTGKTALA LAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIKETKEV YEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHK KKEIIQDVTLHDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEIN KVVNKYIDQGIAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIVIFA SNRGNCVIRGTEDITSPHGIPLDLLDRVMIIRTMLYTPQEMKQIIKIRAQ TEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKINGKDSIEKEHV EEISELFYDAKSSAKILADQQDKYMK
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分子量
52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RUVBL1, a member of the RuvB-like (RUVBL) family of ATPases, plays a crucial role in various cellular processes, including DNA repair, chromatin remodeling, and regulation of gene expression. Its involvement in crucial cellular mechanisms has attracted significant attention from researchers, particularly due to its overexpression in various cancers, which suggests it may function as an oncogene. Studies have indicated that RUVBL1 is essential for the assembly of protein complexes that modulate transcription and the repair of DNA double-strand breaks, thus highlighting its importance in maintaining genomic stability. Moreover, recent findings have implicated RUVBL1 in the regulation of cell proliferation, apoptosis, and even the response to cellular stress. Given its pivotal roles, RUVBL1 is considered a potential target for cancer therapy, and understanding its structure and function through recombinant protein studies can provide insights into its mechanistic role in disease. Research focusing on the purification and characterization of RUVBL1 recombinant protein has the potential to facilitate the development of novel therapeutic strategies aimed at inhibiting its function in oncogenesis. These insights could lead to the identification of new biomarkers for cancer diagnosis and prognosis, highlighting the relevance of RUVBL1 as a promising target in oncology.
