Analytical Data
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基因名
HDAC10
- Application
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别名
HDAC10；Polyamine deacetylase HDAC10
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q969S8
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表达区间
1-482aa
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氨基酸序列
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRL SAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTF HCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNV AIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHG RFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLA FEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQ APHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLD QPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHES LAREEALTALGKLLYLLDGMLDGQVNSGIAAT
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分子量
71 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Histone deacetylase 10 (HDAC10) is a member of the HDAC family, which plays a crucial role in the regulation of gene expression by removing acetyl groups from histones, leading to chromatin condensation and transcriptional repression. Unlike other HDACs, HDAC10 is primarily localized in the cytoplasm and has been implicated in various cellular processes, including cell cycle regulation, differentiation, and apoptosis. Recent studies have highlighted its involvement in several diseases, particularly cancer, where altered HDAC activity contributes to tumorigenesis and poor prognosis. Given its distinct functional characteristics and the potential for HDAC inhibitors as therapeutic agents, HDAC10 has garnered attention as a novel target for drug development. The need for a better understanding of HDAC10's structure and function has propelled research into its recombinant protein expression and purification, allowing for detailed biochemical and biophysical analyses. By utilizing recombinant HDAC10, researchers aim to elucidate its enzymatic properties, identify its substrates, and explore its regulatory mechanisms, thereby providing insights that could lead to the development of targeted therapies for diseases associated with HDAC dysregulation. This research is pivotal in advancing our knowledge of epigenetic regulation and its implications for health and disease.
