Analytical Data
-
基因名
CDK11B
- Application
-
别名
CDK11B；CDC2L1；CDK11；PITSLREA；Cyclin-dependent kinase 11B
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P21127
-
表达区间
1-795aa
-
氨基酸序列
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEE GELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHR KDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWER QKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEE RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK PGEARPARAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE EVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSA LTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYG VVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT LWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLM NKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRG TSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
-
分子量
135 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Recombinant Human ACTR10 Protein，His
Cat：PA2000-5340
Recombinant Human OPN1SW Protein，GST
Cat：PA2000-9850
Recombinant Human SNAP25 Protein，His
Cat：PA1000-2965
Protein Description
CDK11B (Cyclin-dependent kinase 11B) is a serine/threonine kinase that plays a crucial role in regulating cell cycle progression, RNA processing, and transcription. As a member of the cyclin-dependent kinase family, CDK11B is involved in various cellular processes, including the coordination of the G2/M transition and the regulation of the transcriptional machinery via phosphorylation of RNA polymerase II. The study of CDK11B has gained significant interest due to its implications in cancer biology, as aberrant expression or activity of cyclin-dependent kinases can contribute to uncontrolled cell proliferation. Furthermore, CDK11B is known to impact alternative splicing and mRNA stability, linking it to gene expression regulation beyond mere cell cycle control. Recent advancements in proteomics and molecular biology techniques have facilitated the exploration of CDK11B's structure and function, highlighting its potential as a therapeutic target. The generation of recombinant CDK11B proteins allows for detailed functional assays and interactions studies, contributing to a better understanding of its role in cellular processes and disease states. This research not only deepens our comprehension of CDK11B's biochemistry but also paves the way for the development of novel cancer therapies aimed at modulating its activity.
