Analytical Data
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Gene name
OTX1
- Application
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Alternative Names
FLJ38361; Homeobox protein OTX 1; Homeobox protein OTX1; MGC15736; Orthodenticle 1; Orthodenticle homeobox 1; Orthodenticle homolog 1; Orthodenticle1; Otx 1; otx1; OTX1_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P32242
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Expression Region
1-354 aa
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AA Sequence
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG SGTKSRPAKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSSSANPA AAAAAGLGGN PVAAASSLST PAASSIWSPA SISPGSAPAS VSVPEPLAAP SNTSCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPTPSS SYFGGVDCSS YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH HQGYGGSGLA FNSADCLDYK EPGAAAASSA WKLNFNSPDC LDYKDQASWR FQVL
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Molecular Weight
37.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OTX1 (Orthodenticle Homeobox 1) is a transcription factor that plays crucial roles in embryonic development and neurogenesis. It is predominantly expressed in the early stages of brain development and is essential for the proper formation of the forebrain and midbrain structures. Abnormal expression or mutation of OTX1 has been implicated in various neurological disorders and developmental anomalies, including certain types of cancers. As a homeobox gene, OTX1 encodes a protein that binds to specific DNA sequences, regulating the expression of target genes involved in cell differentiation, proliferation, and organogenesis. The study of OTX1 recombinant protein is significant as it allows researchers to investigate the functional properties of this transcription factor at a molecular level. By producing OTX1 as a recombinant protein, scientists can study its structural characteristics, interaction with DNA, and its regulatory mechanisms in cellular processes. Furthermore, understanding how OTX1 functions and its pathway interactions can provide insights into its role in disease and developmental biology, potentially leading to novel therapeutic strategies. Given its importance in neural development and oncogenesis, OTX1 represents a critical target for research aimed at elucidating underlying mechanisms and developing interventions for related pathologies.
