Analytical Data
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Gene name
RGS8
- Application
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Alternative Names
RGS8；Regulator of G-Protein signaling 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P57771
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Expression Region
1-180aa
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AA Sequence
MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA TRWADSFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK LVSKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNLQEPSL TCFDQAQGKV HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS
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Molecular Weight
20.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS8, or Regulator of G-protein Signaling 8, is a member of the RGS protein family, which plays a crucial role in regulating signal transduction pathways mediated by G-proteins. These proteins are pivotal in various physiological processes, including cell proliferation, differentiation, and neurotransmission. The study of RGS8 has gained attention due to its specific involvement in modulating the signaling activity of certain G-protein-coupled receptors (GPCRs), which are key targets in drug development for various diseases, including cardiovascular disorders and neurological conditions. Research has shown that RGS8 can enhance the GTPase activity of Gα subunits, thus promoting the return of the G-protein to its inactive state, effectively terminating the signaling cascade. Furthermore, mutations or alterations in RGS protein levels, including RGS8, have been linked to several pathological conditions. Therefore, the recombination and characterization of RGS8 as a protein offer significant insights into its functional mechanisms and potential therapeutic applications. Ongoing studies focus on the structural biology of RGS8, its interaction with GPCRs, and the development of small molecules that can modulate its activity to influence G-protein signaling pathways purposefully. Understanding these dynamics not only elucidates the biological roles of RGS8 but also contributes to developing innovative treatments targeting GPCR-related diseases, highlighting the importance of RGS8 in both basic and clinical research environments.
