Analytical Data
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基因名
PCSK1N
- Application
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别名
b-LEN; b-PEN-LEN; b-SAAS; Big LEN; granin like neuroendocrine peptide; l-LEN; l-SAAS; N-proSAAS; OTTHUMP00000032426; PCSK1_HUMAN; Pcsk1n; pro-SAAS; Proprotein convertase 1 inhibitor; Proprotein convertase subtilisin/kexin type 1 inhibitor; PROSAAS; SAAS; SAAS CT(1-49); SAAS CT(25-40)
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UHG2
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表达区间
34-260 aa
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氨基酸序列
ARPVKEP RGLSAASPPL AETGAPRRFR RSVPRGEAAG AVQELARALA HLLEAERQER ARAEAQEAED QQARVLAQLL RVWGAPRNSD PALGLDDDPD APAAQLARAL LRARLDPAAL AAQLVPAPVP AAALRPRPPV YDDGPAGPDA EEAGDETPDV DPELLRYLLG RILAGSADSE GVAAPRRLRR AADHDVGSEL PPEGVLGALL RVKRLETPAP QVPARRLLPP
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分子量
27.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCSK1N, or proprotein convertase subtilisin/kexin type 1 inhibitor, is a crucial protein implicated in the regulation of hormone processing and neuropeptide maturation. Its significance is underscored by its role in modulating the activity of proprotein convertases, which are responsible for activating various peptides and proteins, including several hormones involved in metabolic and neurological functions. Abnormalities in PCSK1N expression or function have been linked to a range of metabolic disorders, obesity, and certain neurodegenerative diseases, highlighting the need for understanding its underlying mechanisms. Recent studies have focused on the development of recombinant PCSK1N proteins to facilitate in-depth research into its structure-function relationships, interactions with proprotein convertases, and potential therapeutic applications. By producing and characterizing these recombinant proteins, researchers aim to explore the biological pathways influenced by PCSK1N and assess its potential as a target for therapeutic intervention in diseases associated with its dysregulation. The comprehensive analysis of PCSK1N and its functional roles may pave the way for novel strategies in treating metabolic and neurological disorders, underlining the importance of ongoing research in this area.
