Analytical Data
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基因名
Mcu
- Application
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别名
Mcu；C10orf42；CCDC109A；Calcium uniporter Protein. mitochondrial
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种属
Mouse
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q3UMR5
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表达区间
50-350aa
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氨基酸序列
AHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHEDAATLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLKQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKE
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分子量
39.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MCU (Mitochondrial Calcium Uniporter) is a crucial protein that facilitates the transport of calcium ions into the mitochondria, playing a significant role in regulating cellular calcium homeostasis and energy metabolism. The study of MCU recombinant proteins has gained traction due to the essential functions of mitochondrial calcium in various physiological processes, including ATP production, apoptosis, and metabolic signaling. Furthermore, disturbances in calcium uptake by mitochondria have been implicated in numerous pathologies, such as neurodegenerative diseases, cancer, and cardiovascular disorders. Recombinant MCU proteins are being researched to better understand their structure, function, and regulatory mechanisms. By producing and studying these proteins, researchers aim to uncover the molecular dynamics of MCU and its interactions with other mitochondrial components. This knowledge can pave the way for developing targeted therapies that address mitochondrial dysfunctions associated with various diseases. Furthermore, with advancements in techniques like cryo-electron microscopy and X-ray crystallography, scientists are now able to elucidate the intricate architecture of MCU and its functional implications in live cells. This research is not only significant for advancing our understanding of mitochondrial biology but also for addressing the broader implications of calcium signaling in health and disease.
