Analytical Data
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基因名
CXCR2
- Application
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别名
CXCR2；IL8RB；C-X-C chemokine receptor type 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P25025
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表达区间
1-360aa
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氨基酸序列
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT LPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVH ATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDM GNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAM RVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVG SSSGHTSTTL
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分子量
66 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CXCR2, a C-X-C chemokine receptor type 2, plays a pivotal role in mediating immune responses and inflammation by directing the migration of neutrophils to sites of infection or injury. As a member of the G protein-coupled receptor (GPCR) family, CXCR2 interacts with various chemokines, particularly IL-8, to facilitate cellular signaling pathways that are crucial for leukocyte trafficking. Over the years, researchers have increasingly focused on CXCR2 due to its implications in various pathological conditions, including chronic inflammatory diseases, cancer metastasis, and autoimmune disorders. The development of CXCR2 recombinant proteins has become essential for elucidating its structure-function relationships, understanding its role in signaling mechanisms, and identifying potential therapeutic targets. Recombinant CXCR2 proteins can be utilized in various experimental setups, including ligand-binding studies, functional assays, and crystallography for structural determination. Recent advancements in protein engineering techniques have enabled the production of more stable and functional CXCR2 variants, providing insights into its pharmacological properties and laying the groundwork for drug design. Understanding the intricacies of CXCR2 interactions and its regulatory mechanisms could ultimately lead to innovative therapeutic approaches aimed at modulating inflammatory responses and improving treatment outcomes in diseases where CXCR2 is implicated.
