Analytical Data
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基因名
SMPDL3A
- Application
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别名
SMPDL3A；ASML3A；Cyclic GMP-AMP phosphodiesterase SMPDL3A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92484
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表达区间
23-453aa
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氨基酸序列
LPVAPAGGRNPPPAIGQFWHVTDLHLDPTYHITDDHTKVCASSKGANASN PGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELST DTVINVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVA NLWKPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNIMTLN KTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQNITAMREYYN EKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPV KSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESIWKLEY ILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDK TCKAFQICAIMNLDNISYADCLKQLYIKHNYVDHHHHHH
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分子量
50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SMPDL3A, or sphingomyelin phosphodiesterase acid-like 3A, is an intriguing member of the SMPD gene family, which plays a pivotal role in lipid metabolism and cellular signaling. Research has indicated that SMPDL3A is involved in sphingolipid metabolism, influencing various biological processes including cell proliferation, apoptosis, and inflammation. Abnormal expression or dysfunction of SMPDL3A has been linked to several pathological conditions, such as cancer and neurodegenerative diseases. Due to its substantial impact on cellular homeostasis, understanding the structure and function of recombinant SMPDL3A proteins has become a focal point in biomedical research. The generation of recombinant SMPDL3A offers valuable insights into its enzymatic activity, substrate specificity, and regulatory mechanisms. Furthermore, studying the protein's interactions with other cellular components may reveal novel therapeutic targets for diseases associated with sphingolipid dysregulation. By analyzing recombinant SMPDL3A, researchers aim to elucidate its role in health and disease, potentially leading to innovative strategies for treatment and prevention.
