Analytical Data
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Gene name
TBXAS1
- Application
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Alternative Names
TBXAS1; CYP5; CYP5A1; TXAS; Thromboxane-A synthase; TXA synthase; TXS; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P24557
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Expression Region
357-533aa
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Molecular Weight
24kda
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
TBXAS1 (Thromboxane A Synthase 1) is an enzyme that plays a pivotal role in the biosynthesis of thromboxane A2, a potent vasoconstrictor and platelet aggregator. It is primarily found in vascular tissues and platelets, where it contributes significantly to cardiovascular homeostasis and the regulation of hemostasis. The dysregulation of TBXAS1 has been implicated in various pathological conditions, including cardiovascular diseases, hypertension, and thromboembolic disorders. As research progresses, understanding the structure-function relationship of TBXAS1 and its interaction with other molecular players in the thromboxane pathway has gained importance. Recombinant TBXAS1 protein production enables detailed biochemical and biophysical studies, facilitating insights into its enzymatic mechanisms and potential inhibitors. These studies are crucial for developing therapeutic strategies aimed at modulating thromboxane A2 levels in disease states. Moreover, recombinant TBXAS1 serves as a valuable tool for high-throughput screening of compounds that may have anti-thrombotic effects. This research area continues to evolve, with the goal of elucidating the role of TBXAS1 in health and disease, ultimately contributing to improved cardiovascular therapies and patient outcomes.
