Analytical Data
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基因名
TBX2
- Application
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别名
FLJ10169; HGNC:11597; T box 2; T box transcription factor TBX2; T-box protein 2; T-box transcription factor TBX2; TBX2; TBX2_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13207
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表达区间
1-712 aa
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氨基酸序列
MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALAK PLPDPGLAGA AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE VEDDPKVTLE AKELWDQFHK LGTEMVITKS GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT LPSLRLYEEH CKPERDGAES DASSCDPPPA REPPTSPGAA PSPLRLHRAR AEEKSCAADS DPEPERLSEE RAGAPLGRSP APDSASPTRL TEPERARERR SPERGKEPAE SGGDGPFGLR SLEKERAEAR RKDEGRKEAA EGKEQGLAPL VVQTDSASPL GAGHLPGLAF SSHLHGQQFF GPLGAGQPLF LHPGQFTMGP GAFSAMGMGH LLASVAGGGN GGGGGPGTAA GLDAGGLGPA ASAASTAAPF PFHLSQHMLA SQGIPMPTFG GLFPYPYTYM AAAAAAASAL PATSAAAAAA AAAGSLSRSP FLGSARPRLR FSPYQIPVTI PPSTSLLTTG LASEGSKAAG GNSREPSPLP ELALRKVGAP SRGALSPSGS AKEAANELQS IQRLVSGLES QRALSPGRES PK
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分子量
75.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBX2 is a member of the T-box family of transcription factors, which play pivotal roles in various developmental processes and cellular functions. Research on TBX2 has garnered considerable interest due to its involvement in embryonic development, cell differentiation, and proliferation. Notably, TBX2 has been implicated in tumorigenesis, as its overexpression is associated with several cancer types, including breast and prostate cancer. Enhanced levels of TBX2 can contribute to oncogenic processes by regulating genes involved in cell cycle progression and apoptosis. The functional understanding of TBX2 at the molecular level necessitates the generation of recombinant TBX2 proteins, which allows for detailed studies of its biochemical properties, interaction partners, and downstream gene targets. The production and purification of TBX2 recombinant proteins enable advanced techniques such as electrophoretic mobility shift assays (EMSAs), co-immunoprecipitation, and gene expression analyses, facilitating insights into the mechanisms by which TBX2 exerts its regulatory functions. Furthermore, investigating the structural features of TBX2 through recombinant protein studies can shed light on its role in DNA binding and transcriptional regulation. Overall, the study of recombinant TBX2 proteins is essential to unravel its multifaceted roles in development and cancer, paving the way for potential therapeutic strategies targeting TBX2-related pathways.
