Analytical Data
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Gene name
PROZ
- Application
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Alternative Names
PROZ；Vitamin K-dependent Protein Z
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P22891
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Expression Region
41-400aa
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AA Sequence
AGSYLLEELF EGNLEKECYE EICVYEEARE VFENEVVTDE FWRRYKGGSP CISQPCLHNG SCQDSIWGYT CTCSPGYEGS NCELAKNECH PERTDGCQHF CLPGQESYTC SCAQGYRLGE DHKQCVPHDQ CACGVLTSEK RAPDLQDLPW QVKLTNSEGK DFCGGVIIRE NFVLTTAKCS LLHRNITVKT YFNRTSQDPL MIKITHVHVH MRYDADAGEN DLSLLELEWP IQCPGAGLPV CTPEKDFAEH LLIPRTRGLL SGWARNGTDL GNSLTTRPVT LVEGEECGQV LNVTVTTRTY CERSSVAAMH WMDGSVVTRE HRGSWFLTGV LGSQPVGGQA HMVLVTKVSR YSLWFKQIMN
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PROZ (Protein Z) is a vitamin K-dependent plasma protein involved in the regulation of hemostasis. Its primary function is to act as a cofactor for the plasma protein Z-dependent protease inhibitor (ZPI), which helps to inhibit activated factor X and modulates the coagulation cascade, thereby preventing excessive clot formation. Research into PROZ has gained traction due to its potential associations with various thrombotic disorders and its role in the balance between coagulation and anticoagulation. The recombinant form of PROZ has garnered interest as it allows for in-depth exploration of its biochemical properties and functional mechanisms. With advances in genetic engineering and recombinant DNA technology, scientists have been able to produce PROZ in vitro, enabling detailed studies on its structure-function relationships, post-translational modifications, and interactions with other proteins. Moreover, understanding the role of PROZ in coagulation pathology could lead to novel therapeutic strategies for managing thromboembolic diseases. As such, ongoing research aims to elucidate the precise contributions of PROZ to hemostasis and its potential as a biomarker or therapeutic target in coagulation-related disorders.
