Analytical Data
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基因名
KSR1
- Application
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别名
KSR1；KSR；Kinase suppressor of Ras 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IVT5
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表达区间
335-923aa
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氨基酸序列
PQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKC TKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKE HPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDS RFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAA PLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSS RRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG EVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAI ITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDL KSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIV REMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIG SGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLN RRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM
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分子量
105 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KSR1 (Kinase Suppressor of Ras 1) is a crucial component of the Ras signaling pathway, which plays a significant role in cell proliferation, differentiation, and survival. Research into KSR1 has gained momentum due to its implications in various cancers, where dysregulation of Ras signaling is often observed. KSR1 functions as a scaffolding protein, facilitating the assembly of different signaling molecules to enhance the efficiency of Ras-mediated signal transduction. It interacts with various kinases, including MEK and ERK, which are vital in the MAPK/ERK pathway. Understanding KSR1's structure and function is essential for elucidating its role in normal cellular processes and its contributions to oncogenesis. The generation of recombinant KSR1 proteins has enabled scientists to study its molecular interactions, post-translational modifications, and functional dynamics in vitro and in vivo. These studies are critical for identifying potential therapeutic targets aimed at modulating KSR1 activity in Ras-driven cancers. Given the complexity of KSR1's role in cell signaling, ongoing research focusing on its mechanisms and effects on cellular pathways holds promise for developing novel cancer treatments and better understanding the intricacies of Ras-dependent signaling networks.
