Analytical Data
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Gene name
IL-36γ
- Application
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Alternative Names
IL-36γ
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NZH8
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Expression Region
1-169aa
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AA Sequence
MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND
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Molecular Weight
18.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-36γ, a member of the interleukin-36 (IL-36) cytokine family, has garnered significant attention in recent immunological research due to its pro-inflammatory properties and implications in various autoimmune and inflammatory diseases, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Discovered as a vital player in the innate immune response, IL-36γ is predominantly produced by epithelial cells and plays a crucial role in the activation of immune cells, thereby regulating both the innate and adaptive immune responses. Its interaction with the IL-36 receptor complex leads to the activation of signaling pathways that drive the expression of other pro-inflammatory cytokines, contributing to pathogenic processes in chronic inflammatory conditions. Consequently, the recombinant production of IL-36γ protein has become a pivotal focus for scientists aiming to elucidate its biological functions and therapeutic potential. Research efforts leverage recombinant DNA technology to produce functional IL-36γ, facilitating in vitro and in vivo studies that assess its role in immune modulation and its potential as a therapeutic target. Understanding the mechanistic pathways associated with IL-36γ may pave the way for novel treatment strategies for diseases characterized by dysregulated immune responses. Moreover, the development of IL-36γ antagonists or neutralizing antibodies could offer promising avenues for mitigating inflammation and restoring immune homeostasis in affected patients, thus underscoring the significance of IL-36γ research in contemporary immunology.
