Analytical Data
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Gene name
C18orf37
- Application
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Alternative Names
INO80C; C18orf37; INO80 complex subunit C; IES6 homolog; hIes6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6PI98
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Expression Region
1-192aa
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AA Sequence
MAAQIPIVAT TSTPGIVRNS KKRPASPSHN GSSGGGYGAS KKKKASASSF AQGISMEAMS ENKMVPSEFS TGPVEKAAKP LPFKDPNFVH SGHGGAVAGK KNRTWKNLKQ ILASERALPW QLNDPNYFSI DAPPSFKPAK KYSDVSGLLA NYTDPQSKLR FSTIEEFSYI RRLPSDVVTG YLALRKATSI VP
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Molecular Weight
20.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C18orf37, a gene located on chromosome 18, has gained attention in recent years due to its potential role in various biological processes and diseases. Initially identified through genomic studies, C18orf37 was found to encode a protein whose function remains largely unexplored. Recent research indicates its involvement in cellular mechanisms, particularly in relation to cell proliferation, differentiation, and apoptosis. Additionally, C18orf37 has been implicated in certain genetic disorders, such as Bardet-Biedl syndrome, suggesting a crucial role in the regulation of ciliary function and cellular signaling pathways. The development of recombinant C18orf37 protein has enabled researchers to investigate its biochemical properties, interactions with other cellular components, and potential implications in pathology. Biochemical characterization of C18orf37 has revealed that it may possess enzymatic activity or act as a scaffold for protein complexes, making it a candidate for further studies in genome stability and tissue development. Understanding the function of C18orf37 through recombinant protein studies could provide insights into its role in human health and disease, paving the way for novel therapeutic strategies targeting disorders linked with its dysregulation. Consequently, C18orf37 is positioned as a promising subject for further investigation, with the hope that elucidating its function will contribute to a broader understanding of the molecular underpinnings of related diseases and enhance the potential for clinical applications.
