Analytical Data
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基因名
AIM2
- Application
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别名
AIM2；Interferon-inducible Protein AIM2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14862
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表达区间
1-343aa
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氨基酸序列
MESKYKEILL LTGLDNITDE ELDRFKFFLS DEFNIATGKL HTANRIQVAT LMIQNAGAVS AVMKTIRIFQ KLNYMLLAKR LQEEKEKVDK QYKSVTKPKP LSQAEMSPAA SAAIRNDVAK QRAAPKVSPH VKPEQKQMVA QQESIREGFQ KRCLPVMVLK AKKPFTFETQ EGKQEMFHAT VATEKEFFFV KVFNTLLKDK FIPKRIIIIA RYYRHSGFLE VNSASRVLDA ESDQKVNVPL NIIRKAGETP KINTLQTQPL GTIVNGLFVV QKVTEKKKNI LFDLSDNTGK MEVLGVRNED TMKCKEGDKV RLTFFTLSKN GEKLQLTSGV HSTIKVIKAK KKT
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AIM2 (Absent in Melanoma 2) is a crucial protein that plays a significant role in the innate immune response, particularly in recognizing cytosolic DNA derived from pathogens or damaged host cells. The interest in AIM2 has surged in recent years due to its ability to form inflammasomes, large multi-protein complexes that activate inflammatory responses through caspase-1, leading to the secretion of pro-inflammatory cytokines like IL-1β and IL-18. Studies have shown that dysregulation of AIM2 and its associated pathways can contribute to various diseases, including autoimmune disorders and cancer. Consequently, research efforts have focused on the development of recombinant AIM2 proteins to better understand its structure, function, and role in disease. Characterizing AIM2 in vitro involves producing and purifying recombinant proteins, which are essential for functional assays and structural analyses. Moreover, studying AIM2’s interaction with other proteins and its regulatory mechanisms could unveil potential therapeutic targets to modulate inflammatory responses. Given the protein’s pivotal role, ongoing research aims to elucidate AIM2's complex dynamics within the immune system, which may lead to novel strategies for treating inflammatory diseases, enhancing vaccine efficacy, and combating infections due to its involvement in pathogen detection and immune response activation.
