Analytical Data
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基因名
PTGS2
- Application
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别名
PTGS2；COX2；Prostaglandin G/H synthase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35354
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表达区间
18-601aa
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氨基酸序列
ANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERS
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分子量
70.9kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTGS2, also known as cyclooxygenase-2 (COX-2), is an enzyme that plays a crucial role in the inflammatory response and is involved in the biosynthesis of prostaglandins from arachidonic acid. It is typically induced during inflammation and is associated with various pathophysiological processes, including cancer, cardiovascular diseases, and neurodegenerative disorders. The regulation of PTGS2 expression is complex, with various cytokines, growth factors, and cellular stressors influencing its activity. Given its significant role in disease mechanisms, PTGS2 has emerged as a potential therapeutic target. Research into PTGS2 recombinant proteins aids in understanding enzyme functionality, regulation mechanisms, and interactions with pharmaceutical compounds. The production of PTGS2 recombinant proteins using techniques such as recombinant DNA technology enables detailed biochemical studies and the development of specific inhibitors. These inhibitors hold promise for treating diseases characterized by chronic inflammation and aberrant prostaglandin signaling. Furthermore, the study of PTGS2 through recombinant proteins can facilitate the identification of novel biomarkers for disease diagnosis and prognosis, ultimately contributing to personalized medicine approaches. Understanding PTGS2's structure-function relationship is essential for designing effective therapeutic interventions, making it a focal point of biomedical research in the quest to mitigate inflammatory-related pathologies.
