Analytical Data
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基因名
RAD17
- Application
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别名
CCYC; Cell cycle checkpoint protein; Cell cycle checkpoint protein RAD17; FLJ41520; HRAD 17; hRad17; R24L; Rad 17; Rad 24; RAD1 (S. pombe) homolog; RAD1 homolog; RAD17; RAD17 homolog (S. pombe); RAD17 homolog; Rad17 like protein; RAD17; S. pombe; homolog of; RAD17_HUMAN; RAD17Sp; Rad24; Rad24; mouse; homolog of; Rad24; S. cerevisiae; homolog of; RF C activator 1 homolog; RF C/activator 1 homolog; RF-C/activator 1 homolog
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75943
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表达区间
1-681 aa
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氨基酸序列
MSKTFLRPKV SSTKVTDWVD PSFDDFLECS GVSTITATSL GVNNSSHRRK NGPSTLESSR FPARKRGNLS SLEQIYGLEN SKEYLSENEP WVDKYKPETQ HELAVHKKKI EEVETWLKAQ VLERQPKQGG SILLITGPPG CGKTTTLKIL SKEHGIQVQE WINPVLPDFQ KDDFKGMFNT ESSFHMFPYQ SQIAVFKEFL LRATKYNKLQ MLGDDLRTDK KIILVEDLPN QFYRDSHTLH EVLRKYVRIG RCPLIFIISD SLSGDNNQRL LFPKEIQEEC SISNISFNPV APTIMMKFLN RIVTIEANKN GGKITVPDKT SLELLCQGCS GDIRSAINSL QFSSSKGENN LRPRKKGMSL KSDAVLSKSK RRKKPDRVFE NQEVQAIGGK DVSLFLFRAL GKILYCKRAS LTELDSPRLP SHLSEYERDT LLVEPEEVVE MSHMPGDLFN LYLHQNYIDF FMEIDDIVRA SEFLSFADIL SGDWNTRSLL REYSTSIATR GVMHSNKARG YAHCQGGGSS FRPLHKPQWF LINKKYRENC LAAKALFPDF CLPALCLQTQ LLPYLALLTI PMRNQAQISF IQDIGRLPLK RHFGRLKMEA LTDREHGMID PDSGDEAQLN GGHSAEESLG EPTQATVPET WSLPLSQNSA SELPASQPQP FSAQGDMEEN IIIEDYESDG T
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分子量
77.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAD17 is a pivotal protein involved in the DNA damage response and cell cycle regulation. It is part of a larger complex responsible for sensing DNA lesions and facilitating the activation of the checkpoint pathways that ensure genomic integrity. Research on RAD17 has gained prominence due to its crucial role in the formation of the mediator complex that recruits repair proteins to sites of DNA damage, thus influencing the cellular response to genotoxic stress. Mutations or dysregulation of RAD17 have been implicated in various cancers, highlighting its potential as a biomarker for tumor progression and a target for therapeutic strategies. Moreover, studies have shown that RAD17 interacts with several other proteins, such as the Rad9-Rad1-Hus1 (9-1-1) complex, which further emphasizes its importance in the maintenance of genome stability. Understanding the molecular mechanisms of RAD17 function not only sheds light on the fundamental processes of DNA repair but also opens up avenues for developing novel cancer treatments that could exploit vulnerabilities in the DNA damage response pathways. Given its central role, RAD17 continues to be an area of active research, with ongoing studies aimed at elucidating its precise mechanisms of action and potential implications in oncology and therapeutic interventions.
