Analytical Data
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Gene name
RANGAP1
- Application
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Alternative Names
Fug 1; Fug1; GTPase-activating protein. RAN. 1; KIAA1835; MGC20266; OTTHUMP00000028918; OTTHUMP00000198755; OTTHUMP00000198756; OTTHUMP00000198757; OTTHUMP00000198758; RAGP1_HUMAN; Ran 1; RAN GTPase activating protein 1; Ran GTPase-activating protein 1; Ran1; RANGAP 1; RANGAP; RanGAP1; SD; Segregation distorter homolog; Segregation distortion
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P46060
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Expression Region
2-587 aa
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AA Sequence
ASEDIAKLA ETLAKTQVAG GQLSFKGKSL KLNTAEDAKD VIKEIEDFDS LEALRLEGNT VGVEAARVIA KALEKKSELK RCHWSDMFTG RLRTEIPPAL ISLGEGLITA GAQLVELDLS DNAFGPDGVQ GFEALLKSSA CFTLQELKLN NCGMGIGGGK ILAAALTECH RKSSAQGKPL ALKVFVAGRN RLENDGATAL AEAFRVIGTL EEVHMPQNGI NHPGITALAQ AFAVNPLLRV INLNDNTFTE KGAVAMAETL KTLRQVEVIN FGDCLVRSKG AVAIADAIRG GLPKLKELNL SFCEIKRDAA LAVAEAMADK AELEKLDLNG NTLGEEGCEQ LQEVLEGFNM AKVLASLSDD EDEEEEEEGE EEEEEAEEEE EEDEEEEEEE EEEEEEEPQQ RGQGEKSATP SRKILDPNTG EPAPVLSSPP PADVSTFLAF PSPEKLLRLG PKSSVLIAQQ TDTSDPEKVV SAFLKVSSVF KDEATVRMAV QDAVDALMQK AFNSSSFNSN TFLTRLLVHM GLLKSEDKVK AIANLYGPLM ALNHMVQQDY FPKALAPLLL AFVTKPNSAL ESCSFARHSL LQTLYKV
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Molecular Weight
63.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RANGAP1 (Ran GTPase-activating protein 1) is a critical protein involved in the regulation of the Ran GTPase cycle, which plays a pivotal role in nucleocytoplasmic transport, cell cycle progression, and gene expression. It functions by promoting the hydrolysis of Ran-GTP to Ran-GDP, thereby facilitating the transport of proteins and RNA across the nuclear envelope. The importance of RANGAP1 has garnered attention in various fields, including cancer research, neurobiology, and developmental biology, as its dysregulation is associated with several diseases, including cancer progression and neurodegenerative disorders. The study of RANGAP1 recombinant proteins has advanced our understanding of its structure-function relationship and enabled the exploration of its interactions with other cellular components. By producing and characterizing RANGAP1 in a recombinant form, researchers can investigate its enzymatic activity, binding capabilities, and potential regulatory mechanisms in cell biology. Recent advancements in molecular biology techniques have made it possible to analyze RANGAP1 in greater detail, paving the way for potential therapeutic applications targeting its pathways. The ongoing research into RANGAP1 is vital for developing novel strategies to manipulate its function in disease contexts, emphasizing the need for a deeper understanding of its roles in cellular processes and potential as a biomarker or therapeutic target.
