Analytical Data
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Gene name
C22orf18
- Application
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Alternative Names
CENPM; C22orf18; ICEN39; PANE1Centromere Protein M; CENP-M; Interphase centromere complex Protein 39; Proliferation-associated nuclear element Protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NSP4
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Expression Region
1-180aa
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AA Sequence
MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNRPRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKLAHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL
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Molecular Weight
45.54 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C22orf18, also known as chromosome 22 open reading frame 18, has garnered attention in biochemical and genetic research due to its potential implications in various biological processes and diseases. Initially identified through genomic sequencing efforts, C22orf18 is hypothesized to play a significant role in cellular signaling and metabolic pathways, although its precise function remains largely unexplored. Recent studies have suggested that C22orf18 may be involved in cancer biology, particularly in the context of tumor growth and metastasis, making it a candidate for further investigation in cancer therapy. The generation of recombinant C22orf18 protein allows researchers to study its structure and function in detail. By expressing this protein in suitable expression systems, scientists can analyze its interactions with other cellular components and elucidate its role in downstream signaling pathways. Investigating the post-translational modifications and localization patterns of C22orf18 can provide insights into its functional mechanisms. Furthermore, understanding the implications of C22orf18 in disease pathology could reveal novel therapeutic targets, paving the way for innovative treatment strategies. Overall, the study of C22orf18 recombinant protein is a crucial step in unraveling the biological significance of this enigmatic protein and its potential impact on human health.
