Analytical Data
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基因名
LMP2
- Application
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别名
LMP2；Lysosome-associated membrane glycoProtein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P13285
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表达区间
1-497aa
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氨基酸序列
MGSLEMVPMGAGPPSPGGDPDGYDGGNNSQYPSASGSSGNTPTPPNDEERESNEEPPPPYEDPYWGNGDRHSDYQPLGTQDQSLYLGLQHDGNDGLPPPPYSPRDDSSQHIYEEAGRGSMNPVCLPVIVAPYLFWLAAIAASCFTASVSTVVTATGLALSLLLLAAVASSYAAAQRKLLTPVTVLTAVVTFFAICLTWRIEDPPFNSLLFALLAAAGGLQGIYVLVMLVLLILAYRRRWRRLTVCGGIMFLACVLVLIVDAVLQLSPLLGAVTVVSMTLLLLAFVLWLSSPGGLGTLGAALLTLAAALALLASLILGTLNLTTMFLLMLLWTLVVLLICSSCSSCPLSKILLARLFLYALALLLLASALIAGGSILQTNFKSLSSTEFIPNLFCMLLLIVAGILFILAILTEWGSGNRTYGPVFMCLGGLLTMVAGAVWLTVMSNTLLSAWILTAGFLIFLIGFALFGVIRCCRYCCYYCLTLESEERPPTPYRNTV
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分子量
54.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LMP2, or low molecular weight protein 2, is a crucial component of the immunoproteasome, which plays a vital role in the processing of antigens for presentation by Major Histocompatibility Complex (MHC) class I molecules. This protein is encoded by the LMP2 gene and is induced by inflammatory cytokines, contributing to the immune response during viral infections and other pathological conditions. Research into LMP2 recombinant protein has gained significance due to its importance in the regulation of immune responses and potential therapeutic applications. The ability to produce LMP2 as a recombinant protein allows for detailed structural and functional studies that can enhance our understanding of its role in the immune system. Moreover, LMP2 is of interest in the context of cancer immunotherapy, as it may influence the tumor microenvironment and impact the efficacy of immune checkpoint inhibitors. Studying LMP2 also opens avenues for vaccine development, particularly in designing strategies that enhance T-cell responses by improving antigen presentation. Additionally, insights derived from LMP2 research may contribute to developing treatments for autoimmune diseases, where the immune response is dysregulated. Thus, the investigation of LMP2 recombinant protein not only enriches our knowledge of immune mechanisms but also holds potential for innovative therapeutic approaches in various diseases.
