Analytical Data
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基因名
C9orf32
- Application
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别名
AD 003; Alpha N-terminal Protein methyltransferase 1A; C9orf32; Chromosome 9 open reading frame 32; Methyltransferase like 11A; Methyltransferase-like Protein 11A; Mettl11a; N-terminal RCC1 methyltransferase; NRMT
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BV86
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表达区间
1-223aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSEFMTSEV IEDEKQFYSK AKTYWKQIPP TVDGMLGGYG HISSIDINSS RKFLQRFLRE GPNKTGTSCA LDCGAGIGRI TKRLLLPLFR EVDMVDITED FLVQAKTYLG EEGKRVRNYF CCGLQDFTPE PDSYDVIWIQ WVIGHLTDQH LAEFLRRCKG SLRPNGIIVI KDNMAQEGVI LDDVDSSVCR DLDVVRRIIC SAGLSLLAEE RQENLPDEIY HVYSFALR
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分子量
28 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C9orf32, or Chromosome 9 Open Reading Frame 32, is a gene that has garnered significant attention in the field of neurodegenerative disease research, particularly in relation to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The emergence of hexanucleotide repeat expansions (GGGGCC) within the intron of the C9orf32 gene has been identified as a major genetic cause of these disorders, affecting a substantial proportion of familial cases. The resulting protein product, although still not fully understood, is believed to play a crucial role in cellular processes such as RNA metabolism and stress response. Research studies have increasingly focused on the biophysical and biochemical properties of recombinant C9orf32 protein to elucidate its pathogenic mechanisms and interactions within the neuronal environment. Understanding the structure and function of the C9orf32 protein can provide insights into the molecular pathways leading to neurodegeneration, potentially paving the way for the development of targeted therapeutic strategies. Furthermore, examining the effects of C9orf32 protein disruptions can help delineate the interplay between genetic mutations and environmental factors in the onset of neurodegenerative diseases. Overall, investigations into C9orf32 and its recombinant protein are essential for advancing our knowledge of ALS and FTD, ultimately contributing to improved diagnosis and treatment options for affected individuals.
