Analytical Data
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基因名
BZLF1
- Application
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别名
BZLF1；Ubinuclein-1
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种属
E.coli
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P03206
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表达区间
1-245aa
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氨基酸序列
MMDPNSTSEDVKFTPDPYQVPFVQAFDQATRVYQDLGGPSQAPLPCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQNQQTNQAGGEAPQPGDNSTVQTAAAVVFACPGANQGQQLADIGVPQPAPVAAPARRTRKPQQPESLEECDSELEIKRYKNRVASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLLKQMCPSLDVDSIIPRTPDVLHEDLLNF
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分子量
42. 9kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BZLF1, a key immediate-early protein encoded by the Epstein-Barr virus (EBV), plays a crucial role in regulating the viral lifecycle and reactivation from latency. Research on BZLF1 has gained significant attention due to its dual function as a transcription factor and a modulator of the host immune response. Understanding BZLF1's mechanisms is essential for unraveling the complexities of EBV pathogenesis, as this virus is associated with various diseases, including infectious mononucleosis, lymphoproliferative disorders, and certain types of cancer, such as Burkitt lymphoma and Hodgkin's lymphoma. BZLF1 activates the expression of early lytic genes while simultaneously repressing certain cellular genes, which helps evade the immune system. Furthermore, the protein's ability to interact with host cell factors suggests it may influence cellular signaling pathways affecting cell growth and apoptosis. By studying BZLF1 in detail, researchers aim to develop targeted therapeutic strategies that could mitigate EBV-related diseases and enhance our understanding of viral latency and reactivation mechanisms. Overall, the investigation of BZLF1 and its recombinant protein forms holds promise not only for basic virology but also for potential clinical applications in treating viral infections and malignancies associated with EBV.
