Analytical Data
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基因名
COL4A3
- Application
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别名
COL4A3；Collagen alpha-3(IV) chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q01955
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表达区间
1428-1670aa
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氨基酸序列
LKG KRGDSGSPAT WTTRGFVFTR HSQTTAIPSC PEGTVPLYSG FSFLFVQGNQ RAHGQDLGTL GSCLQRFTTM PFLFCNVNDV CNFASRNDYS YWLSTPALMP MNMAPITGRA LEPYISRCTV CEGPAIAIAV HSQTTDIPPC PHGWISLWKG FSFIMFTSAG SEGTGQALAS PGSCLEEFRA SPFLECHGRG TCNYYSNSYS FWLASLNPER MFRKPIPSTV KAGELEKIIS RCQVCMKKRH
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分子量
31 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COL4A3, or collagen type IV alpha 3 chain, is a crucial component of the basal membrane and plays a significant role in maintaining the structural integrity of various tissues, including the kidney, lungs, and blood vessels. Mutations in the COL4A3 gene are associated with several diseases, most notably Alport syndrome, which is characterized by progressive renal failure, hearing loss, and eye abnormalities. The study of recombinant COL4A3 protein has become increasingly important for understanding its functional properties and exploring its potential therapeutic applications. By generating recombinant COL4A3 in various expression systems, researchers can investigate its role in extracellular matrix formation, cell adhesion, and tissue repair processes. Additionally, recombinant COL4A3 serves as a valuable tool for studying pathogenic mechanisms and developing novel treatment strategies for related disorders. As our understanding of COL4A3's molecular mechanics grows, it opens avenues for gene therapies and regenerative medicine, providing hope for patients affected by disorders linked to this essential protein. The ongoing research aims to elucidate not only the fundamental biology of COL4A3 but also to translate these findings into clinical solutions.
