Analytical Data
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基因名
RNF121
- Application
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别名
RNF121; RING finger protein 121
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H920
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表达区间
193-301 aa
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氨基酸序列
ERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVSEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLD
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分子量
37.73 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF121 is a novel protein that belongs to the RING finger protein family, which plays a significant role in various cellular processes, including the regulation of protein stability, cell proliferation, and apoptosis. Emerging research indicates that RNF121 acts as an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent degradation of target proteins involved in cellular signaling pathways. This function is crucial in maintaining cellular homeostasis and responding to stress, which links RNF121 to key physiological and pathological conditions, including cancer progression and immune response modulation. Studies have suggested that dysregulation of RNF121 may contribute to oncogenesis, making it a potential biomarker for cancer diagnosis and a target for therapeutic intervention. Additionally, RNF121's involvement in the autophagy process further emphasizes its importance in cellular metabolism and survival. Recent advancements in recombinant protein technologies have enabled the production of RNF121, allowing researchers to explore its structural and functional characteristics in greater detail. Understanding the precise mechanisms of RNF121 may provide insights into its roles in disease processes and pave the way for novel therapeutic strategies. Overall, RNF121 represents a promising subject of study in molecular biology, with implications for understanding complex disease mechanisms and developing innovative treatment approaches.












