Analytical Data
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基因名
CLEC4M
- Application
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别名
CLEC4M；CD209L；CD209L1；CD299；C-type lectin domain family 4 member M
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H2X3
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表达区间
78-399aa
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氨基酸序列
SLSQEQSEQD AIYQNLTQLK AAVGELSEKS KLQEIYQELT QLKAAVGELP EKSKLQEIYQ ELTRLKAAVG ELPEKSKLQE IYQELTRLKA AVGELPEKSK LQEIYQELTR LKAAVGELPE KSKLQEIYQE LTELKAAVGE LPEKSKLQEI YQELTQLKAA VGELPDQSKQ QQIYQELTDL KTAFERLCRH CPKDWTFFQG NCYFMSNSQR NWHDSVTACQ EVRAQLVVIK TAEEQNFLQL QTSRSNRFSW MGLSDLNQEG TWQWVDGSPL SPSFQRYWNS GEPNNSGNED CAEFSGSGWN DNRCDVDNYW ICKKPAACFR DE
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分子量
65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLEC4M, also known as DC-SIGN (Dendritic Cell-Specific ICAM-3-Grabbing Non-integrin), is a C-type lectin receptor predominantly expressed on dendritic cells and macrophages. It plays a crucial role in immune response by recognizing and binding various pathogens, including viruses and bacteria, thus facilitating their uptake and presentation to T cells. Research into CLEC4M has gained significance due to its involvement in several infectious diseases, including HIV, dengue, and tuberculosis, as it serves as a major entry point for these pathogens into host cells. Understanding the structural and functional aspects of CLEC4M is essential for developing novel therapeutic strategies and vaccines. Recent studies have focused on the receptor’s role in modulating immune responses, its interaction with microbial components, and the implications of genetic polymorphisms in susceptibility to infections. Moreover, the potential use of CLEC4M as a biomarker for disease progression and prognosis is being explored, highlighting its significance in both basic and clinical immunology research. The ongoing investigation into the reorganization of CLEC4M not only elucidates its biological function but also contributes to the broader understanding of immune regulation and host-pathogen interactions.
